South San Diego Vacations

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Where to stay in South San Diego

Find the best South San Diego areas and neighborhoods for the activities you enjoy most. Learn more about South San Diego
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Otay Mesa West

Even though there aren't top sights in Otay Mesa West, you can explore the larger area and take in top sights like San Ysidro Border Crossing. Jump on the metro at Iris Avenue Trolley Station to see more of the city.

Find hotels in Otay Mesa West

Find the Best South San Diego Vacation Packages

South San Diego Hotel Deals

The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is ₩213,700 per night from Feb 23 to Feb 24
₩213,700
₩240,830 total
includes taxes & fees
Feb 23 - Feb 24
8.6/10 Excellent! (3,182 reviews)
"Was okay"

Reviewed on Feb 20, 2025

The Dana on Mission Bay
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is ₩230,409 per night from Mar 16 to Mar 17
₩230,409
₩259,659 total
includes taxes & fees
Mar 16 - Mar 17
8.2/10 Very Good! (5,610 reviews)
"Only downside for me was cost to park a car ($50/day)"

Reviewed on Feb 19, 2025

Wyndham San Diego Bayside
Omni San Diego Hotel
Omni San Diego Hotel
4 out of 5
675 L St, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is ₩251,277 per night from Mar 16 to Mar 17
₩251,277
₩346,210 total
includes taxes & fees
Mar 16 - Mar 17
9/10 Wonderful! (1,843 reviews)
"Nice location and hotel"

Reviewed on Feb 20, 2025

Omni San Diego Hotel
See all 7,433 properties in South San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a South San Diego vacation package cost?
Chart your own course with our South San Diego vacation packages, which start from only . Select the flights and hotels that suit your travel style. Then, add on a few sightseeing activities for an unforgettable escape.
How do I get a cheap travel package to South San Diego?
Browse and book everything all in one place with our South San Diego vacation packages. You’ll find deals on hotels, flights, tours and more that’ll keep your pocketbook happy and your spirit of adventure alive. And, with more than 550 partner airlines and 1,000,000 hotel options around the world to choose from, there are endless opportunities to mix and match as you like.
What are the top hotels in South San Diego?
Have a look at Wyndham San Diego Bayside and Manchester Grand Hyatt San Diego. They’re top picks for lots of travelers to Chula Vista. If Imperial Beach features on your itinerary, Hard Rock Hotel San Diego and Best Western Plus Marina Gateway Hotel are two top-notch options.
How far in advance should I book my South San Diego vacation?
Travelers can normally compare international fares on Expedia up to a year in advance of departure. Booking late? With a little bit of luck, it’s still possible to score a cheaper ticket just weeks before your journey.
What does an Expedia South San Diego travel package include?
Flights, hotels and a shiny set of wheels for all your road trip adventures. Simply select your preferred bundle and get access to incredible deals. Once you’ve made your booking, add on a couple of tours and activities and watch your savings pile up. When it comes to crafting your South San Diego escape, you’re the boss!
What should I know before booking a South San Diego travel package?
A package can be easier on the wallet than separately booking everything you need for your escape. For example, bundle your flights, hotels and rental cars and save a packet. Whatever sort of vacation you’re planning, you’re sure to find a package within your budget.
Can I choose my airline with a South San Diego Expedia vacation package?
With a vacation package, you’re in charge. Whether you’re eager to fly to South San Diego in economy or business class, simply select from the available airline options. Expedia has access to over 550 airline partners around the world.
If I'm not able to travel, can I cancel my South San Diego vacation package?
You can. We realize things don’t always go to plan, so we’re here to help if you need to make changes to your South San Diego vacation package. It may be possible to cancel or amend your itinerary at no cost if you’ve booked in the last 24 hours. Your airline, hotel or car rental company may charge you a fee if you booked more than 24 hours ago. Visit our Customer Service Portal for further information. Also, be sure to check your itinerary for the finer details on change fees.

Discover the most popular places to visit in South San Diego

Kaiser Permanente Otay Mesa Medical Offices

4.5/5(3 reviews)

Though Kaiser Permanente Otay Mesa Medical Offices might be what brings you to town, perhaps you'll have a chance to explore more of San Diego while you are here.

Kaiser Permanente Otay Mesa Medical Offices

Atlantis Laser Tag

You can take time to visit Atlantis Laser Tag during your travels to Chula Vista. Wander the waterfront and beautiful beaches in this family-friendly area.

Atlantis Laser Tag
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.