Find hotels in Cayo Guillermo

  • Plan, book, stay with confidence
  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check Cayo Guillermo hotel prices

Tomorrow night
This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Compare 7 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Save an average of 15% on thousands of hotels when you're signed in

Frequently asked questions

What's the best place for a stay in Cayo Guillermo?

Hotel Grand Muthu Cayo Guillermo is one of the top choices for your stay based on our traveler data. This hotel features satellite TV and minibars. Other good options for your trip include Villa Gregorio and Iberostar Daiquirí - All inclusive. See all available top hotels, or vacation rentals in Cayo Guillermo.

If I need to cancel my hotel reservation in Cayo Guillermo, will I receive a refund?

Yes, most hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, you might still have the option to cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Cayo Guillermo.

Where can I learn more about changing or cancelling my trip to Cayo Guillermo?

For more information about rescheduling or cancelling your trip to Cayo Guillermo, head over to our customer service page.

What's the best accommodation for a family trip to Cayo Guillermo?

Iberostar Daiquirí - All inclusive is a property with 2 outdoor pools and a free kids' club, and it's a top choice on Expedia for families. Find more child-friendly accommodations in Cayo Guillermo.

What's the best place to stay for a couple going to Cayo Guillermo?

Sol Cayo Guillermo - All Inclusive is a favorite property for couples, and features rainfall showerheads and 4 restaurants. Another choice for your romantic getaway is Iberostar Daiquirí - All inclusive. See all romantic hotels in Cayo Guillermo.

What's the best accommodation for an all-inclusive stay in Cayo Guillermo?

Iberostar Daiquirí - All inclusive is an all-inclusive property featuring 3 restaurants and 2 outdoor pools, and a favorite with Expedia travelers. Club Cayo Guillermo - All Inclusive is another good choice for your stay. See more all-inclusive resorts in Cayo Guillermo.

What's the best pet-friendly place to stay in Cayo Guillermo?

Sol Cayo Guillermo - All Inclusive is a top property for people traveling with their pets, and offers 4 restaurants and an outdoor pool for its human guests. See more pet-friendly hotel accommodations in Cayo Guillermo.

Where is the best place to stay with easy access to Cayo Guillermo Beach?

Adjacent to Cayo Guillermo Beach, Iberostar Daiquirí is one of the top choices for your stay based on our traveler data, and this 4-star property offers 2 outdoor pools and 3 restaurants. Other good options within a short distance include Sol Cayo Guillermo - All Inclusive and Club Cayo Guillermo - All Inclusive.

What about the best place to stay close to Cayo Guillermo Marina?

One of the top choices for your stay is Iberostar Daiquirí, located a short 0.8 mi (1.3 km) from Cayo Guillermo Marina, and this 4-star property offers 2 outdoor pools and 3 restaurants. Club Cayo Guillermo - All Inclusive, located just 0.4 mi (0.7 km) away, is another good option for your stay.

What's the best place for a beach vacation in Cayo Guillermo?

Villa Gregorio is a top beachfront hotel with free breakfast and free parking, and it's located close to Cayo Guillermo Beach. Other good choices for your beach trip include Iberostar Daiquirí - All inclusive and Club Cayo Guillermo - All Inclusive. See more stays near the beach in Cayo Guillermo.

What's the best luxury accommodation in Cayo Guillermo?

Iberostar Daiquirí is a 4-star property with 3 restaurants and 4 bars, and it's a popular choice for Expedia travelers looking for a pampering stay. Find more luxury hotels in Cayo Guillermo.

What are some hotels with pools in Cayo Guillermo?

Sol Cayo Guillermo - All Inclusive is a top property with a children's pool, an outdoor pool, and 4 restaurants. View all hotels with pools in Cayo Guillermo.

What is the best spa hotel in Cayo Guillermo?

Sol Cayo Guillermo - All Inclusive is a top beach spa hotel featuring 4 restaurants, 5 bars, a pool, and a fitness center. Enjoy a massage at the on-site spa. Other popular spa hotels in Cayo Guillermo include Iberostar Daiquirí - All inclusive and Club Cayo Guillermo - All Inclusive. See all spa hotels in Cayo Guillermo.

What is staying in Cayo Guillermo like?

Visitors can enjoy all that Cayo Guillermo has to offer including the local tours, entertainment choices, and beaches. In Cayo Guillermo, there are 4 hotels and other accommodations to choose from. Find out more about Cayo Guillermo.

What should I do while I'm visiting Cayo Guillermo?

A favorite place to visit is Cayo Guillermo Beach. Additionally, you'll find Parque Natural el Bagá in the area. Check out what more to see and do in Expedia's Cayo Guillermo guide.

What's the weather like in Cayo Guillermo?

The hottest months are usually August and September with an average temp of 83°F, while the coldest months are January and March with an average of 76°F. Average annual precipitation for Cayo Guillermo is 45 inches.